Tocilizumab

Research use only, not for human use.

Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.

Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.

Cell Proliferation Assay Cell Line:Human-derived HARA-B cells Concentration:1 ng/mL, 10 ng/mL, and 100 ng/mL Incubation Time:24 hours, 48 hours Result:Inhibited the IL-6R expressed on human-derived HARA-B cells.Cell Cytotoxicity Assay Cell Line:Ba/F3-gp130-IL-6R cells Concentration:0.001–10000 μg/ml Incubation Time:2 days Result:Inhibited Ba/F3-gp130-IL-6R cell proliferation. Western Blot Analysis Cell Line:SAS cells Concentration:1 μM Incubation Time:6 hours Result:Reduced the phosphorylation of STAT3.RT-PCR Cell Line:SAS cells Concentration:1-5 μM Incubation Time:24 hoursResult:Reduced VEGF mRNA expression.

Animal Model:A brain metastasis model of lung tumor cells by inoculating HARA-B cells in nude mice Dosage:1.0 mg/100 μL Administration:Intravenous injection; 1.0 mg/100 μL; twice a week, three weeks Result:Led the volume of each metastatic focus significantly smaller.Animal Model:SCID mice with SAS cells Dosage:100 μg/mL Administration:Intraperitoneal injection;100 μg/mL; every 48 hours; 20days Result:Suppressed the growth of advanced tumors.

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Apoptosis

IL Receptor

IL Receptor

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375823-41-9

148 kDa

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years